TY - JOUR TI - Enantioselective synthesis of sulfoxides: 2000-2009 AU - Wojaczyńska, E. AU - Wojaczyński, J. T2 - Chemical Reviews AB - Various achievements in the field of enantioselective synthesis of sulfoxides in years 2000-2009 are compiled. A series of (4-X-benzyl) p-tolyl sulfoxides was prepared in both enantiomeric forms using the Andersen method. Diastereomers of S-oxidized N-protected S-methyl or S-propyl-L-cysteine methyl ester were prepared using the DAG methodology and was found that the diastereomeric ratio is stongly dependent on the combination of solvent and base. While identifying the best method for the preparation of nonracemic modafinil derivatives, it was found that chiral oxaziridines give better results than metal-based systems. Studies on the sulfoxidation of the series of 2-arylsulfanylpyrroles demonstrated that the synthetic Kagan and Modena protocols could be applied with success if the electron-withdrawing groups differentiated the two substituents of the sulfur atom. DA - 2010/// PY - 2010 DO - 10.1021/cr900147h DP - Scopus VL - 110 IS - 7 SP - 4303 EP - 4356 ST - Enantioselective synthesis of sulfoxides DB - Scopus ER -