TY - JOUR TI - Synthesis and Cytotoxic Activity of Chiral Sulfonamides Based on the 2-Azabicycloalkane Skeleton AU - Samadaei, Mahzeiar AU - Pinter, Matthias AU - Senfter, Daniel AU - Madlener, Sibylle AU - Rohr-Udilova, Nataliya AU - Iwan, Dominika AU - Kamińska, Karolina AU - Wojaczyńska, Elżbieta AU - Wojaczyński, Jacek AU - Kochel, Andrzej T2 - Molecules AB - A series of chiral sulfonamides containing the 2-azabicycloalkane scaffold were prepared from aza-Diels–Alder cycloadducts through their conversion to amines based on 2-azanorbornane or the bridged azepane skeleton, followed by the reaction with sulfonyl chlorides. The cytotoxic activity of the obtained bicyclic derivatives was evaluated using human hepatocellular carcinoma (HCC), medulloblastoma (MB), and glioblastoma (GBM) cell lines. Chosen compounds were shown to notably reduce cell viability as compared to nonmalignant cells. DA - 2020/01// PY - 2020 DO - 10.3390/molecules25102355 DP - www.mdpi.com VL - 25 IS - 10 SP - 2355 LA - en UR - https://www.mdpi.com/1420-3049/25/10/2355 Y2 - 2020/05/29/11:14:30 KW - 2-azabicycloalkane KW - Chiral sulfonamide KW - Cytotoxic activity KW - chiral sulfonamide KW - cytotoxic activity ER -